Design and synthesis of novel prodrugs of 2'-deoxy-2'-methylidenecytidine activated by membrane dipeptidase overexpressed in tumor tissues.

@article{Kohchi2007DesignAS,
  title={Design and synthesis of novel prodrugs of 2'-deoxy-2'-methylidenecytidine activated by membrane dipeptidase overexpressed in tumor tissues.},
  author={Yasunori Kohchi and Kazuo Hattori and Nobuhiro Oikawa and Eisaku Mizuguchi and Yoshiaki Isshiki and Kohsuke Aso and Kiyoshi Yoshinari and Haruyoshi Shirai and Masanori Miwa and Yukiko Inagaki and Masako Ura and Kotaroh Ogawa and Hisafumi Okabe and Hideo Ishitsuka and Nobuo Shimma},
  journal={Bioorganic & medicinal chemistry letters},
  year={2007},
  volume={17 8},
  pages={2241-5}
}
DNA microarray analysis comparing human tumor tissues with normal tissues including hematopoietic progenitor cells resulted in identification of membrane dipeptidase as a prodrug activation enzyme. Novel prodrugs of 2'-deoxy-2'-methylidenecytidine (DMDC) including compound 23 that are activated by membrane dipeptidase (MDP) preferentially in tumor tissue… CONTINUE READING