Design and synthesis of new trehalose‐conjugated pentapeptides as inhibitors of Aβ(1–42) fibrillogenesis and toxicity

@article{Bona2009DesignAS,
  title={Design and synthesis of new trehalose‐conjugated pentapeptides as inhibitors of A$\beta$(1–42) fibrillogenesis and toxicity},
  author={Paolo de Bona and Maria Laura Giuffrida and F. Caraci and A. Copani and B. Pignataro and F. Attanasio and S. Cataldo and G. Pappalardo and E. Rizzarelli},
  journal={Journal of Peptide Science},
  year={2009},
  volume={15}
}
Aggregation of the amyloid Aβ peptide and its accumulation into insoluble deposits (plaques) are believed to be the main cause of neuronal dysfunction associated with Alzheimer's disease (AD); small molecules that can interfere with the Aβ amyloid fibril formation are therefore of interest for a potential therapeutic strategy. Three new trehalose‐conjugated peptides of the well known β‐sheet breaker peptide iAβ5p, were synthesized. The disaccharide was covalently attached to different sites of… Expand
Ac‐LPFFD‐Th: A Trehalose‐Conjugated Peptidomimetic as a Strong Suppressor of Amyloid‐β Oligomer Formation and Cytotoxicity
Modulation of Amyloid β-Protein (Aβ) Assembly by Homologous C-Terminal Fragments as a Strategy for Inhibiting Aβ Toxicity.
The iAβ5p β-breaker peptide regulates the Aβ(25-35) interaction with lipid bilayers through a cholesterol-mediated mechanism.
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