Design and synthesis of long‐chain arylpiperazines with mixed affinity for serotonin transporter (SERT) and 5‐HT1A receptor

  title={Design and synthesis of long‐chain arylpiperazines with mixed affinity for serotonin transporter (SERT) and 5‐HT1A receptor},
  author={Roberto Perrone and Francesco Berardi and Nicola Antonio Colabufo and Enza Lacivita and Carmela Larizza and Marcello Leopoldo and Vincenzo Tortorella},
  journal={Journal of Pharmacy and Pharmacology},
A new generation of antidepressant agents could be represented by compounds with mixed activity as serotonin transporter (SERT) inhibitors and 5‐HT1A receptor antagonists. We report here on the synthesis and evaluation of SERT and 5‐HT1A receptor affinity of long‐chain arylpiperazines obtained either by modifying 6‐nitroquipazine into a long‐chain arylpiperazine or by inserting a modified 6‐nitroquipazine moiety or other structures endowed with SERT affinity into a long‐chain arylpiperazine… Expand
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