Design and synthesis of fluorescent probes for selective detection of highly reactive oxygen species in mitochondria of living cells.

@article{Koide2007DesignAS,
  title={Design and synthesis of fluorescent probes for selective detection of highly reactive oxygen species in mitochondria of living cells.},
  author={Yuichiro Koide and Yasuteru Urano and Suguru Kenmoku and Hirotatsu Kojima and Tetsuo Nagano},
  journal={Journal of the American Chemical Society},
  year={2007},
  volume={129 34},
  pages={
          10324-5
        }
}
We designed and synthesized fluorescent probes for the sensitive and selective detection of highly reactive oxygen species (hROS) in mitochondria of living cells and confirmed their usefulness in vitro. MitoAR and MitoHR are highly selective for hROS (•OH, ONOO-, OCl-) over other ROS. They have exellent properties, including tolerance to autoxidation and photobleaching by laser irradiation during fluorescence microscopy and should be useful tools for biological and pathological applications. 

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