Design and synthesis of dipeptide mimetics of the brain-derived neurotrophic factor


Low-molecular-weight mimetics of loops 1 and 4 of the brain-derived neurotrophic factor (BDNF) have been designed and synthesized. The compounds represent monomeric and dimeric amides of N-acyldipeptides. Their dipeptide fragments coincide in sequence with the central regions of beta-turns of the corresponding neurotrophin loops, and acyl groups are the… (More)
DOI: 10.1134/S1068162012030053


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