Design and synthesis of dipeptide mimetics of the brain-derived neurotrophic factor

Abstract

Low-molecular-weight mimetics of loops 1 and 4 of the brain-derived neurotrophic factor (BDNF) have been designed and synthesized. The compounds represent monomeric and dimeric amides of N-acyldipeptides. Their dipeptide fragments coincide in sequence with the central regions of beta-turns of the corresponding neurotrophin loops, and acyl groups are the… (More)
DOI: 10.1134/S1068162012030053

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.