Design and synthesis of 6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives as neuraminidase inhibitors.

@article{Lou2014DesignAS,
  title={Design and synthesis of 6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives as neuraminidase inhibitors.},
  author={Jun Lou and Xiaoyan Yang and Zhigang Rao and Wenwen Qi and Jinhui Li and Haiyu Wang and Yuxi Li and Jinping Li and Zhiming Wang and Xianming Hu and Peng Liu and Xuechuan Hong},
  journal={European journal of medicinal chemistry},
  year={2014},
  volume={83},
  pages={466-73}
}
A series of 6-oxo-1,4,5,6-tetrahydropyrimidine-5-carboxylate derivatives were prepared to evaluate their ability of inhibiting neuraminidase (NA) of influenza A virus. All the compounds were synthesized in good yields starting from aldehyde by using a suitable synthetic strategy, which showed moderate inhibitory activity against influenza A NA. Compound 6g… CONTINUE READING