Design and synthesis of certain novel bicoumarin de rivatives as anticancer agents

@inproceedings{Abdellatif2016DesignAS,
  title={Design and synthesis of certain novel bicoumarin de rivatives as anticancer agents},
  author={Khaled R A Abdellatif and Mohamed Abdelrahman Mohamed Abdelgawad and Heba A. H. Elshemy and Nesma M. Kahk},
  year={2016}
}
New Bicoumarin derivatives 5a-cwere synthesized through condensation of 3-acetylco umarin derivatives with coumarin acid hydrazide. All the prepared compounds were evaluated for their in vitro anticancer activ ity against human hepatic (Hep-G2) and human breast (MCF-7)canc er cell lines. The prepared compounds showed variab le anticancer activity against Hep-G2 cell line with c ompound 5c being the most potent with IC 50 1.21 mg/mL.Also, compound 5a showed moderate activity with IC 50 4.62 mg… CONTINUE READING

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