Design and synthesis of 2-phenyl-1,4-dioxa-spiro[4.5]deca-6,9-dien-8-ones as potential anticancer agents starting from cytotoxic spiromamakone A.

@article{Fuse2013DesignAS,
  title={Design and synthesis of 2-phenyl-1,4-dioxa-spiro[4.5]deca-6,9-dien-8-ones as potential anticancer agents starting from cytotoxic spiromamakone A.},
  author={Shinichiro Fuse and Kennichi Inaba and Motoki Takagi and Masahiro Tanaka and Takatsugu Hirokawa and Kohei Johmoto and Hidehiro Uekusa and Kazuo Shin‐ya and Takashi Takahashi and Takayuki Doi},
  journal={European journal of medicinal chemistry},
  year={2013},
  volume={66},
  pages={
          180-4
        }
}
The Design, Synthesis, and Evaluation of 1,5,7-Trisubstituted-3-Pyridyl-Xanthones for Use as Insecticides Starting from Pyripyropene A.
TLDR
A readily accessible template of 1,5,7-trisubstituted-3-pyridyl-xanthones was designed starting from naturally occurring pyripyropene A and one of the synthesized compounds retained insecticidal activity against vetch aphid and green peach aphid.
Total Synthesis of Spiromamakone A and Structure Revision of Spiropreussione A.
TLDR
The synthesis using optically active intermediates enabled identification of the racemization step of spiromamakone A and revealed that spiropreussione A are identical; the latter had been reported as a constitutional isomer of the other.
Facile, One‐Step Synthesis of 5‐Substituted Thieno[3,4‐c]pyrrole‐4,6‐dione by Palladium‐Catalyzed Carbonylative Amidation
Described herein is a facile, one-step synthesis of 5-substituted thieno[3,4-c]pyrrole-4,6-diones (TPDs) by a palladium-catalyzed carbonylative amidation of commercially available dibromoaryl
Synthesis of Spiromamakone A Benzo Analogues via Double Oxa-Michael Addition of 1,8-Dihydroxynaphthalene.
TLDR
The cytotoxicity of benzo analogues and synthetic intermediates against cervical carcinoma HeLa cells shows the necessity of the 4-cyclopentene-1,3-dione moiety for biological activity.
Rapid Synthesis of Thiophene-Based, Organic Dyes for Dye-Sensitized Solar Cells (DSSCs) by a One-Pot, Four-Component Coupling Approach.
TLDR
Evaluation of the photovoltaic properties of the solar cells that were prepared using the synthesized dyes revealed that the introduction of an EDOT structure beside a cyanoacrylic acid moiety improved the short-circuit current (Jsc) while decreasing the fill factor (FF).
Elucidation of the structure-property relationship of p-type organic semiconductors through rapid library construction via a one-pot, Suzuki-Miyaura coupling reaction.
TLDR
D-π-A structure, 32 p-type organic semiconductors were rapidly synthesized via a one-pot, Suzuki-Miyaura coupling with subsequent Knoevenagel condensation, and it was revealed that the measured solubility was strongly correlated with thesolubility parameter (SP), as reported by Fedors.
Dual sources of antimicrobial activity of Anemopsis californica : Plant and endophytic fungi
TLDR
The findings suggest that the majority of activity of crude A. californica root extracts against nontuberculous mycobacteria can be attributed to the presence of sesamin and asarinin, the first reported isolation of these compounds from a member of the Saururaceae family.
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