Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure.

@article{Seenisamy2005DesignAS,
  title={Design and synthesis of an expanded porphyrin that has selectivity for the c-MYC G-quadruplex structure.},
  author={Jeyaprakashnarayanan Seenisamy and Sridevi Bashyam and Vijay Gokhale and Hariprasad Vankayalapati and Daekyu Sun and Adam Siddiqui-Jain and Nicole Streiner and Kazuo Shin-Ya and Elizabeth White and W. David Wilson and Laurence H Hurley},
  journal={Journal of the American Chemical Society},
  year={2005},
  volume={127 9},
  pages={
          2944-59
        }
}
Cationic porphyrins are known to bind to and stabilize different types of G-quadruplexes. Recent studies have shown the biological relevance of the intramolecular parallel G-quadruplex as a transcriptional silencer in the c-MYC promoter. TMPyP4 also binds to this G-quadruplex and most likely converts it to a mixed parallel/antiparallel G-quadruplex with two external lateral loops and one internal propeller loop, suppressing c-MYC transcriptional activation. To achieve therapeutic selectivity by… CONTINUE READING
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