Design and synthesis of affinity ligands and relation of their structure with adsorption of proteins.

@article{Ye2011DesignAS,
  title={Design and synthesis of affinity ligands and relation of their structure with adsorption of proteins.},
  author={Long Ye and Aizhang Xu and Chao Cheng and Li Zhang and Chenxi Huo and Feiyun Huang and Hong Xu and Shanshan Li},
  journal={Journal of separation science},
  year={2011},
  volume={34 22},
  pages={
          3145-50
        }
}
Affinity chromatography has played an increasingly important role both in the pharmaceutical industry and academic research. In the present study, we report our preliminary investigation on the relationship between the affinity ligand structure and its adsorption to multi-protein samples. The structure of the ligands, including the size of the ring (cyclic group) and the length of the chain (linear group), has a great impact on the adsorption of ligands to proteins. Meanwhile, the functional… CONTINUE READING
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