Design and synthesis of a multivalent fluorescent folate-calix[4]arene conjugate: cancer cell penetration and intracellular localization.

@article{Consoli2015DesignAS,
  title={Design and synthesis of a multivalent fluorescent folate-calix[4]arene conjugate: cancer cell penetration and intracellular localization.},
  author={Grazia M L Consoli and Giuseppe Granata and Giorgia Fragassi and Mauro Grossi and Michele Sallese and Corrada Geraci},
  journal={Organic & biomolecular chemistry},
  year={2015},
  volume={13 11},
  pages={3298-307}
}
A novel fluorescently labeled folate conjugate in which four folic acid units are covalently conjugated with a 7-nitro-benzofurazan fluorophore by means of a calix[4]arene platform was synthesized by using a Cu-catalyzed azide-alkyne cycloaddition reaction (click chemistry). The synthesized construct (FA-C4-NBD) was characterized by mass spectrometry, NMR… CONTINUE READING