Design and synthesis of N-(pyridylacryl) amino acid derivatives as potential radiosensitizers against HeLa-S3 cells in vitro.

Abstract

A new series of N-(pyridylacryl) amino acid derivatives have been designed and synthesized as potential radiosensitizers in an effort to increase therapeutic efficacy with less toxicity. Radiosensitization and cytotoxicity of the newly synthesized compounds upon HeLa-S3 cells were measured. The main effects of the reduction of the shoulder width and Do… (More)

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