Design and synthesis of 3-isoxazolidone derivatives as new Chlamydia trachomatis inhibitors.

@article{Abdelsayed2014DesignAS,
  title={Design and synthesis of 3-isoxazolidone derivatives as new Chlamydia trachomatis inhibitors.},
  author={S. Abdelsayed and N. T. Ha Duong and J. Hai and M. H{\'e}madi and J. El Hage Chahine and P. Verbeke and N. Serradji},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2014},
  volume={24 16},
  pages={
          3854-60
        }
}
Chlamydia trachomatis (Ct) is a bacterial human pathogen responsible for the development of trachoma, the worldwide infection leading to blindness, and is also a major cause of sexually transmitted diseases. As iron is an essential metabolite for this bacterium, iron depletion presents a promising strategy to limit Ct proliferation. The aim of this study is to synthesize 3-isoxazolidone derivatives bearing known chelating moieties in an attempt to develop new bactericidal anti-Chlamydiaceae… Expand
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