Design and synthesis of 3'- and 5'-O-(3-benzenesulfonylfuroxan-4-yl)-2'-deoxyuridines: biological evaluation as hybrid nitric oxide donor-nucleoside anticancer agents.

@article{Moharram2004DesignAS,
  title={Design and synthesis of 3'- and 5'-O-(3-benzenesulfonylfuroxan-4-yl)-2'-deoxyuridines: biological evaluation as hybrid nitric oxide donor-nucleoside anticancer agents.},
  author={S. Moharram and Aihua Zhou and L. Wiebe and E. Knaus},
  journal={Journal of medicinal chemistry},
  year={2004},
  volume={47 7},
  pages={
          1840-6
        }
}
A group of 3'-O- and 5'-O-(3-benzenesulfonylfuroxan-4-yl)-2'-deoxyuridines possessing a variety of substituents (H, Me, I, F, CF(3)) at the C-5 position of the nucleoside moiety were synthesized for evaluation as hybrid anticancer agents that have the ability to simultaneously release cytotoxic nitric oxide (*NO). Incubation of these nitric oxide donor-nucleoside conjugates in the presence of 18 mM L-cysteine released a high percentage of *NO (21-48% at 1 h; 37-86% at 16 h). The release of *NO… Expand
Synthesis and anticancer activity of some 5-fluoro-2'-deoxyuridine phosphoramidates.
1,2,5-Oxadiazoles
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