Design and synthesis of 2-N-substituted indazolone derivatives as non-carboxylic acid glycogen synthase activators.


Glycogen synthase (GS) catalyzes the transfer of glucose residues from UDP-glucose to a glycogen polymer chain, a critical step for glucose storage. Patients with type 2 diabetes normally exhibit low glycogen levels and decreased muscle glucose uptake is the major defect in whole body glucose disposal. Therefore, activating GS may provide a potential… (More)
DOI: 10.1016/j.bmcl.2013.03.049


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