Design and synthesis of 10-alkoxy-5, 6-dihydro-triazolo[4,3-d]benzo[f][1,4]oxazepine derivatives with anticonvulsant activity.

Abstract

A series of novel 10-alkoxy-5, 6-dihydro-triazolo[4,3-d]benzo[f][1,4]oxazepine derivatives were synthesized and screened for their anticonvulsant activities by the maximal electroshock (MES) test and their neurotoxicity was evaluated by the rotarod neurotoxicity test (Tox). In the MES test, compound 10-Heptyloxy-5, 6-dihydro-triazolo[4,3-d]benzo[f][1,4… (More)
DOI: 10.1016/j.ejmech.2010.03.041

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@article{Deng2010DesignAS, title={Design and synthesis of 10-alkoxy-5, 6-dihydro-triazolo[4,3-d]benzo[f][1,4]oxazepine derivatives with anticonvulsant activity.}, author={Xian-Qing Deng and Cheng-Xi Wei and Fu-Nan Li and Zhi-gang Sun and Zhe Quan}, journal={European journal of medicinal chemistry}, year={2010}, volume={45 7}, pages={3080-6} }