Design and studies of multiple mechanism of anti-Candida activity of a new potent Trp-rich peptide dendrimers.

@article{Zieliska2015DesignAS,
  title={Design and studies of multiple mechanism of anti-Candida activity of a new potent Trp-rich peptide dendrimers.},
  author={Paulina Zielińska and Monika Staniszewska and Małgorzata Bondaryk and Mirosława Koronkiewicz and Zofia Urbańczyk-Lipkowska},
  journal={European journal of medicinal chemistry},
  year={2015},
  volume={105},
  pages={106-19}
}
PURPOSE Eight peptide dendrimers were designed as structural mimics of natural cationic amphiphilic peptides with antifungal activity and evaluated for their anti-Candida potential against the wild type strains and mutants. METHODS Dendrimer 14 containing four Trp residues and dodecyl tail and a slightly smaller dendrimer 9 decorated with four N-methylated Trp that displayed 100 and 99.7% of growth inhibition at 16 μg/mL respectively, were selected for evaluation against the Candida albicans… CONTINUE READING
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