Design and structural analysis of aromatic inhibitors of type II dehydroquinase from Mycobacterium tuberculosis.

Abstract

3-Dehydroquinase, the third enzyme in the shikimate pathway, is a potential target for drugs against tuberculosis. Whilst a number of potent inhibitors of the Mycobacterium tuberculosis enzyme based on a 3-dehydroquinate core have been identified, they generally show little or no in vivo activity, and were synthetically complex to prepare. This report… (More)
DOI: 10.1002/cmdc.201402298

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