Design and solid phase synthesis of new DOTA conjugated (+)-biotin dimers planned to develop molecular weight-tuned avidin oligomers.

@article{Pratesi2015DesignAS,
  title={Design and solid phase synthesis of new DOTA conjugated (+)-biotin dimers planned to develop molecular weight-tuned avidin oligomers.},
  author={Alessandro Pratesi and Mauro Ginanneschi and Fabrizio Melani and Marco Chinol and Angela Carollo and Giovanni Paganelli and Marco Lumini and Mattia Bartoli and Marco Frediani and L. Rosi and Giorgio Petrucci and Luigi Messori and Anna Maria Papini},
  journal={Organic & biomolecular chemistry},
  year={2015},
  volume={13 13},
  pages={
          3988-4001
        }
}
Chemical modifications of the biotin carrier in pretargeted avidin–biotin radionuclide therapy may be of paramount importance for tuning the amount of the radioactivity delivered to cancer cells by labelled biotins. We report here the synthesis of a collection of new synthetic DOTA-constructs bearing two (+)-biotin molecules (bis-biotins), designed for the creation of multimeric Av units (tetramers) bonded to the antibody. All the syntheses were carried out following the solid phase strategy… CONTINUE READING