Design and rationale of CURRENT-OASIS 7: a randomized, 2 x 2 factorial trial evaluating optimal dosing strategies for clopidogrel and aspirin in patients with ST and non-ST-elevation acute coronary syndromes managed with an early invasive strategy.

@article{Mehta2008DesignAR,
  title={Design and rationale of CURRENT-OASIS 7: a randomized, 2 x 2 factorial trial evaluating optimal dosing strategies for clopidogrel and aspirin in patients with ST and non-ST-elevation acute coronary syndromes managed with an early invasive strategy.},
  author={Shamir R. Mehta and Jean-Pierre Bassand and Susan Chrolavicius and Rafael D{\'i}az and Keith A. A. Fox and Christopher B. Granger and Sanjit S. Jolly and H Rupprecht and Petr Widimsk{\'y} and Salim Yusuf},
  journal={American heart journal},
  year={2008},
  volume={156 6},
  pages={1080-1088.e1}
}
BACKGROUND Antiplatelet therapy with clopidogrel and acetylsalicylic acid (ASA) reduces major cardiovascular events in patients with ST and non-ST-segment-elevation acute coronary syndromes (ACS). Recent mechanistic and clinical data suggest that higher loading and maintenance doses of clopidogrel may achieve a more rapid and greater degree of platelet inhibition that translates into improved clinical outcomes, but this is yet to be formally evaluated in an adequately powered randomized trial… CONTINUE READING

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