Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil.

@article{Villar2012DesignAO,
  title={Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil.},
  author={Ana Maria Sierra Villar and Beatriz Clares Naveros and Ana Cristina Calpena Campmany and Monserrat Ar{\'o}ztegui Trenchs and Coloma Barb{\'e} Rocabert and Lyda Halbaut Bellowa},
  journal={International journal of pharmaceutics},
  year={2012},
  volume={431 1-2},
  pages={161-75}
}
Self-nanoemulsifying drug delivery systems of gemfibrozil were developed under Quality by Design approach for improvement of dissolution and oral absorption. Preliminary screening was performed to select proper components combination. Box-Behnken experimental design was employed as statistical tool to optimize the formulation variables, X(1) (Cremophor(®) EL), X(2) (Capmul(®) MCM-C8), and X(3) (lemon essential oil). Systems were assessed for visual characteristics (emulsification efficacy… CONTINUE READING