Design and optimisation of orally active TLR7 agonists for the treatment of hepatitis C virus infection.

@article{Tran2011DesignAO,
  title={Design and optimisation of orally active TLR7 agonists for the treatment of hepatitis C virus infection.},
  author={T. Tran and D. Pryde and Peter Jones and F. Adam and N. Benson and G. Bish and F. Calo and G. Ciaramella and R. Dixon and Jonathan Duckworth and D. Fox and D. Hay and James R. Hitchin and N. Horscroft and Martin Howard and I. Gardner and H. Jones and C. Laxton and T. Parkinson and Gemma C. Parsons and Katie J. W. Proctor and Mya C. Smith and Nicholas N. Smith and A. Thomas},
  journal={Bioorganic \& medicinal chemistry letters},
  year={2011},
  volume={21 8},
  pages={
          2389-93
        }
}
The synthesis and structure-activity relationships of a series of novel interferon inducers are described. Pharmacokinetic studies and efficacy assessment of a series of 8-oxo-3-deazapurine analogues led to the identification of compound 33, a potent and selective agonist of the TLR7 receptor with an excellent in vivo efficacy profile in a mouse model. 
Discovery of a highly potent series of TLR7 agonists.
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