Design and in vivo evaluation of oxycodone once-a-day controlled-release tablets

@inproceedings{Kim2015DesignAI,
  title={Design and in vivo evaluation of oxycodone once-a-day controlled-release tablets},
  author={Ju-Young Kim and S H Lee and Chun-Woong Park and Y S Rhee and Dong-Wook Kim and Junsang Park and Moonseok Lee and Jeong-Woong Seo and Eun Seok Park},
  booktitle={Drug design, development and therapy},
  year={2015}
}
The aim of present study was to design oxycodone once-a-day controlled-release (CR) tablets and to perform in vitro/in vivo characterizations. Release profiles to achieve desired plasma concentration versus time curves were established by using simulation software and reported pharmacokinetic parameters of the drug. Hydroxypropyl methylcellulose (HPMC) 100,000 mPa·s was used as a release modifier because the polymer was found to be resistant to changes in conditions of the release study… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 30 references

Charac - terization and validation of a pharmacokinetic model for controlled - release oxycodone

JW Mandena, RF Kaiko, B Oshlack, RF Reder, DR Stanski
J Control Release • 2013

Effect of ionic strength and pH of dissolution media on theophylline release from hypromellose matrix tablets – Apparatus USP III , simulated fasted and fed conditions

NA Kasim, M Whitehouse, C Ramachandran
Carbohydr Polym • 2011

Influence of ionic strength on matrix integrity and drug release from hydroxypropyl cellulose compacts

J Johnson, J Holinej, M Williams
Pharm Dev Technol • 2006

Molecular properties of WHO essential drugs and provisional biopharmaceutical classification

J Siepmann, H Kranz, R Bodmeier, N Peppas
Mol Pharm • 2004

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