Design and in vivo evaluation of oxycodone once-a-day controlled-release tablets

  title={Design and in vivo evaluation of oxycodone once-a-day controlled-release tablets},
  author={Ju-Young Kim and S H Lee and Chun-Woong Park and Y S Rhee and Dong-Wook Kim and Junsang Park and Moonseok Lee and Jeong-Woong Seo and Eun Seok Park},
  booktitle={Drug design, development and therapy},
The aim of present study was to design oxycodone once-a-day controlled-release (CR) tablets and to perform in vitro/in vivo characterizations. Release profiles to achieve desired plasma concentration versus time curves were established by using simulation software and reported pharmacokinetic parameters of the drug. Hydroxypropyl methylcellulose (HPMC) 100,000 mPa·s was used as a release modifier because the polymer was found to be resistant to changes in conditions of the release study… CONTINUE READING


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