Design and in vivo characterization of kidney-targeting multimodal micelles for renal drug delivery

@article{Wang2018DesignAI,
  title={Design and in vivo characterization of kidney-targeting multimodal micelles for renal drug delivery},
  author={J. Wang and Christopher Poon and Deborah Chin and Sarah Milkowski and V. Lu and K. Hallows and Eun Ji Chung},
  journal={Nano Research},
  year={2018},
  volume={11},
  pages={5584-5595}
}
  • J. Wang, Christopher Poon, +4 authors Eun Ji Chung
  • Published 2018
  • Medicine
  • Nano Research
  • One in three Americans is at risk for developing chronic kidney disease (CKD) and end-stage renal disease (ESRD), leading to the need for dialysis or a kidney transplant. Small-molecule drugs have been proposed as therapies to manage kidney diseases, but high dosages are often required to achieve therapeutic efficacy, generating off-target side effects, some of which are lethal. To address these limitations, we developed a novel, kidney-targeting multimodal micelle (KM) system for drug delivery… CONTINUE READING
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