Design and evaluation of small peptides mapping the exposed surface of IL-8.

@article{Thompson1996DesignAE,
  title={Design and evaluation of small peptides mapping the exposed surface of IL-8.},
  author={Scott K Thompson and Daniel F. Veber and Anthony J. Jurewicz and Catherine E Peishoff and Jae Mok Lee and John R. White},
  journal={International journal of peptide and protein research},
  year={1996},
  volume={47 3},
  pages={214-8}
}
In an effort to determine which regions of IL-8 are involved in interactions with its receptors, eight peptides were designed to correspond to distinct exposed regions of the IL-8 monomer, using the proton NMR-derived structure of the dimer as a basis. The peptides were evaluated singularly, and as equimolar mixtures of two to six peptides, in an IL-8 receptor binding assay and found to have no binding interaction with either alpha or beta IL-8 receptor as single peptides or mixtures of two… CONTINUE READING