Design and evaluation of levodopa methyl ester intranasal delivery systems.

@article{Chun2011DesignAE,
  title={Design and evaluation of levodopa methyl ester intranasal delivery systems.},
  author={Inkoo Chun and Yeon Hong Lee and Kyung Eun Lee and Hye sun Gwak},
  journal={Journal of Parkinson's disease},
  year={2011},
  volume={1 1},
  pages={
          101-7
        }
}
OBJECTIVES This study aimed to examine the feasibility of nasal powder formulations for the delivery of levodopa (L-dopa) into the brain using highly water-soluble levodopa methyl ester hydrochloride (LDME). METHODS For designing nasal LDME powders, pH-rate stabilities of LDME in buffer solutions and their enzymatic degradations in rabbit nasal mucosal and serosal extracts were investigated. In vitro permeation studies were carried out with four LDME nasal powders. RESULTS LDME was degraded… 

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References

SHOWING 1-10 OF 23 REFERENCES
Pharmacokinetic evaluation and modeling of formulated levodopa intranasal delivery systems.
Enhancement of the Systemic and CNS Specific Delivery of L-Dopa by the Nasal Administration of Its Water Soluble Prodrugs
TLDR
Utilization of water soluble prodrugs of L-dopa via the nasal route in the treatment of Parkinson's disease may have therapeutic advantages such as improved bioavailability, decreased sideeffects, and potentially enhanced CNS delivery.
Improved nasal absorption of salmon calcitonin by powdery formulation with N-acetyl-L-cysteine as a mucolytic agent.
Nasal absorption enhancement of insulin by sodium deoxycholate in combination with cyclodextrins.
TLDR
Combining beta-CD with SDC lowered the serious nasal ciliotoxicity of SDC and had a marked absorption promoting effect, which was not due to low concentration of S DC but was related with the inhibition of LAP activity.
Mucosal drug delivery using cellulose derivatives as a functional polymer.
  • Y. Suzuki, Y. Makino
  • Biology
    Journal of controlled release : official journal of the Controlled Release Society
  • 1999
Impact of Gastric Emptying on Levodopa Pharmacokinetics in Parkinson Disease Patients
TLDR
Fine tuning of LD application, which considers gastric emptying, becomes more and more essential in advanced PD stages with a reduced striatal neuronal dopamine capacity, which is responsible for maintenance of motor response in early PD patients.
Intranasal delivery: physicochemical and therapeutic aspects.
The effects of a normal protein diet on levodopa plasma kinetics in advanced Parkinson's disease.
Cyclodextrins in drug delivery: An updated review
TLDR
Cyclodextrins, because of their continuing ability to find several novel applications in drug delivery, are expected to solve many problems associated with the delivery of different novel drugs through different delivery routes.
Levels of dopamine in blood and brain following nasal administration to rats.
  • M. Dahlin, B. Jansson, E. Björk
  • Biology, Medicine
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2001
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