Design and evaluation of gastroretentive mucoadhesive cephalexin tablets.


The aim of this investigation was to develop gastroretentive mucoadhesive tablets of cephalexin, which will retain in the stomach for 10 h. Cephalexin, a first-generation cephalosporin, becomes ionized in intestinal pH because pKa is 4.5 and thus reducing its bioavailability. The various batches were prepared by wet granulation method using variety of… (More)
DOI: 10.1080/10837450903085426


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