Design and evaluation of bilayered buccal film preparations for local administration of lidocaine hydrochloride.

@article{Preis2014DesignAE,
  title={Design and evaluation of bilayered buccal film preparations for local administration of lidocaine hydrochloride.},
  author={Maren Preis and Christina Woertz and Katharina Schneider and Jennifer Kukawka and Jens Broscheit and Norbert Roewer and J{\"o}rg Breitkreutz},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2014},
  volume={86 3},
  pages={
          552-61
        }
}
Bilayered oromucosal film preparations (buccal films) offer a promising way to enable drug administration via the oral cavity. Adding a non-soluble or slowly eroding/dissolving backing layer to a mucoadhesive drug-loaded layer enables unidirectional drug delivery. The aim of this study was to investigate different approaches to the manufacture of bilayered films and to examine their properties by applying different characterization methods including an optimized experimental setup for the study… CONTINUE READING
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