Design and evaluation of a liposomal delivery system targeting the posterior segment of the eye.

@article{Hironaka2009DesignAE,
  title={Design and evaluation of a liposomal delivery system targeting the posterior segment of the eye.},
  author={Kohei Hironaka and Yuta Inokuchi and Yuichi Tozuka and Masamitsu Shimazawa and Hideaki Hara and Hirofumi Takeuchi},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2009},
  volume={136 3},
  pages={247-53}
}
The purpose of this study was to evaluate the potential of submicron-sized liposomes (ssLips) as a novel system for delivering ocular drugs to the eye's posterior segment. Fluorescence emission of coumarin-6 formulated into ssLip was obvious in that segment in mice after eyedrop administration of the liposomal suspension. Such fluorescence was not observed after administration of either multilamellar vesicles or dimethyl sulfoxide (DMSO) solution containing the same amount of coumarin-6. The… CONTINUE READING
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