Design and evaluation of Trypanosoma brucei metacaspase inhibitors.


Metacaspase (MCA) is an important enzyme in Trypanosoma brucei, absent from humans and differing significantly from the orthologous human caspases. Therefore MCA constitutes a new attractive drug target for antiparasitic chemotherapeutics, which needs further characterization to support the discovery of innovative drug candidates. A first series of… (More)
DOI: 10.1016/j.bmcl.2010.01.099


Cite this paper

@article{Berg2010DesignAE, title={Design and evaluation of Trypanosoma brucei metacaspase inhibitors.}, author={Maya Berg and Pieter van der Veken and Jurgen Joossens and Venkatraj Muthusamy and Matthias Breugelmans and Catherine X. Moss and Jana Rudolf and P. G. de Cos and Graham H. Coombs and Louis Maes and Achiel Haemers and Jeremy C Mottram and Koen Augustyns}, journal={Bioorganic & medicinal chemistry letters}, year={2010}, volume={20 6}, pages={2001-6} }