Design and evaluation of Lumefantrine – Oleic acid self nanoemulsifying ionic complex for enhanced dissolution

  title={Design and evaluation of Lumefantrine – Oleic acid self nanoemulsifying ionic complex for enhanced dissolution},
  author={Ketan V. Patel and Vidur Sarma and Pradeep Ratilal Vavia},
  booktitle={DARU Journal of Pharmaceutical Sciences},
Lumefantrine, an antimalarial molecule has very low and variable bioavailability owing to its extremely poor solubility in water. It is recommended to be taken with milk to enhance its solubility and bioavailability. The aim of present study was to develop a Self Nanoemulsifying Delivery system (SNEDs) of lumefantrine (LF) to achieve rapid and complete dissolution independent of food-fat and surfactant in dissolution media. Solubility of LF in oil, co-solvent/co-surfactant and surfactant… CONTINUE READING


Publications citing this paper.
Showing 1-7 of 7 extracted citations


Publications referenced by this paper.
Showing 1-10 of 20 references

Nagarsenker MS: Duloxetine HCl lipid nanoparticles: preparation, characterization, and dosage form design

KD Patel, SG Padhye
AAPS Pharm Sci Tech • 2012
View 1 Excerpt

Vavia PR: Rice Germ Oil as Multifunctional Excipient in Preparation of Self- Microemulsifying Drug Delivery System (SMEDDS) of Tacrolimus

SK Pawar
AAPS PharmSciTech • 2012
View 1 Excerpt

Development and Validation of a Dissolution Test Method for Artemether and Lumefantrine in Tablets

P Umapathi, J Ayyappan, SD Quine
Trop J Pharm Res • 2011
View 2 Excerpts

Rheological investigation of self-emulsification process: effect of co-surfactant.

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques • 2009
View 1 Excerpt

Similar Papers

Loading similar papers…