Design and evaluation of Lumefantrine – Oleic acid self nanoemulsifying ionic complex for enhanced dissolution

@inproceedings{Patel2012DesignAE,
  title={Design and evaluation of Lumefantrine – Oleic acid self nanoemulsifying ionic complex for enhanced dissolution},
  author={Ketan V. Patel and Vidur Sarma and Pradeep Ratilal Vavia},
  booktitle={DARU Journal of Pharmaceutical Sciences},
  year={2012}
}
Lumefantrine, an antimalarial molecule has very low and variable bioavailability owing to its extremely poor solubility in water. It is recommended to be taken with milk to enhance its solubility and bioavailability. The aim of present study was to develop a Self Nanoemulsifying Delivery system (SNEDs) of lumefantrine (LF) to achieve rapid and complete dissolution independent of food-fat and surfactant in dissolution media. Solubility of LF in oil, co-solvent/co-surfactant and surfactant… CONTINUE READING

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