Design and efficient synthesis of novel arylthiourea derivatives as potent hepatitis C virus inhibitors.


A novel class of arylthiourea HCV inhibitors bearing various functionalities, such as cyclic urea, cyclic thiourea, urea, and thiourea, on the alkyl linker were designed and synthesized. Herein we report the synthesis and structure-activity relationships (SARs) of this novel class of arylthiourea derivatives that showed potent inhibitory activities against… (More)
DOI: 10.1016/j.bmcl.2009.09.037