Design and development of water-soluble curcumin conjugates as potential anticancer agents.

@article{Safavy2007DesignAD,
  title={Design and development of water-soluble curcumin conjugates as potential anticancer agents.},
  author={Ahmad Safavy and Kevin P. Raisch and Sushma Mantena and Leisa L Sanford and S W Simon Sham and N. Rama Krishna and James A. Bonner},
  journal={Journal of medicinal chemistry},
  year={2007},
  volume={50 24},
  pages={6284-8}
}
Conjugates of curcumin to two differently sized poly(ethylene glycol) molecules were synthesized in an attempt to overcome the low aqueous solubility of this natural product with cytotoxic activity against some human cancer cell lines. The soluble conjugates exhibited enhanced cytotoxicity as compared to that of the parent drug. Synthesis, analyses of the rate of drug release, and cytotoxicity studies are herein reported. The water-soluble conjugates may provide information useful for the… CONTINUE READING
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