Design and development of polymers for gene delivery

@article{Pack2005DesignAD,
  title={Design and development of polymers for gene delivery},
  author={Daniel W Pack and Allan S. Hoffman and Suzie H. Pun and Patrick S. Stayton},
  journal={Nature Reviews Drug Discovery},
  year={2005},
  volume={4},
  pages={581-593}
}
The lack of safe and efficient gene-delivery methods is a limiting obstacle to human gene therapy. Synthetic gene-delivery agents, although safer than recombinant viruses, generally do not possess the required efficacy. In recent years, a variety of effective polymers have been designed specifically for gene delivery, and much has been learned about their structure–function relationships. With the growing understanding of polymer gene-delivery mechanisms and continued efforts of creative… Expand

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