Design and development of nanocomposite scaffolds for auricular reconstruction.

  title={Design and development of nanocomposite scaffolds for auricular reconstruction.},
  author={Leila Nayyer and Martin Birchall and Alexander M. Seifalian and Gavin Jell},
  journal={Nanomedicine : nanotechnology, biology, and medicine},
  volume={10 1},
UNLABELLED Auricular reconstruction using sculpted autologous costal cartilage is effective, but complex and time consuming and may incur donor site sequelae and morbidity. Conventional synthetic alternatives are associated with infection and extrusion in up to about 15% of cases. We present a novel POSS-PCU nanocomposite auricular scaffold, which aims to reduce extrusion rates by mimicking the elastic modulus of human ears and by encouraging desirable cellular interactions. The fabrication… CONTINUE READING
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