Design and development of ligand-appended polysaccharidic nanoparticles for the delivery of oxaliplatin in colorectal cancer.

@article{Jain2010DesignAD,
  title={Design and development of ligand-appended polysaccharidic nanoparticles for the delivery of oxaliplatin in colorectal cancer.},
  author={Anekant Jain and Sanjay Kumar Jain and Narayanan Shankar Ganesh and Jaya Barve and Aadil M Beg},
  journal={Nanomedicine : nanotechnology, biology, and medicine},
  year={2010},
  volume={6 1},
  pages={
          179-90
        }
}
UNLABELLED Hyaluronic acid-coupled chitosan nanoparticles bearing oxaliplatin (L-OHP) encapsulated in Eudragit S100-coated pellets were developed for effective delivery to colon tumors. The in vitro drug release was investigated using a USP dissolution rate test paddle-type apparatus in different simulated gastrointestinal tract fluids. In therapeutic experiments the pellets of free drug, and hyaluronic acid-coupled and uncoupled chitosan nanoparticles bearing L-OHP were administered orally at… CONTINUE READING
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