Design and development of benzoxazole derivatives with toll-like receptor 9 antagonism.

Abstract

Toll-like receptor 9 (TLR9) is a major therapeutic target for numerous inflammatory disorders. Development of small molecule inhibitors for TLR9 remains largely empirical due to lack of structural understanding of potential TLR9 antagonism by small molecules and due to the unusual topology of the ligand binding surface of the receptor. To develop a… (More)
DOI: 10.1016/j.ejmech.2017.03.086

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