Design and characterization of an improved protein tyrosine phosphatase substrate-trapping mutant.

@article{Xie2002DesignAC,
  title={Design and characterization of an improved protein tyrosine phosphatase substrate-trapping mutant.},
  author={Laiping Xie and Yan-ling Zhang and Zhong-Yin Zhang},
  journal={Biochemistry},
  year={2002},
  volume={41 12},
  pages={4032-9}
}
Although members of the protein tyrosine phosphatase (PTPase) family share a common mechanism of action (hydrolysis of phosphotyrosine), the cellular processes in which they are involved can be both highly specialized and fundamentally important. Identification of cellular PTPase substrates will help elucidate the biological functions of individual PTPases. Two types of substrate-trapping mutants are being used to isolate PTPase substrates. In the first, the active site Cys residue is replaced… CONTINUE READING

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