Design and characterization of a novel amphiphilic chitosan nanocapsule-based thermo-gelling biogel with sustained in vivo release of the hydrophilic anti-epilepsy drug ethosuximide.

@article{Hsiao2012DesignAC,
  title={Design and characterization of a novel amphiphilic chitosan nanocapsule-based thermo-gelling biogel with sustained in vivo release of the hydrophilic anti-epilepsy drug ethosuximide.},
  author={Meng-Hsuan Hsiao and Mikael Larsson and Anette Larsson and Hanne Evenbratt and Y. Chen and You-Yin Chen and Dean-Mo Liu},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2012},
  volume={161 3},
  pages={942-8}
}
Thermo-gelling injectable nanogels, with no burst release of loaded drug, were prepared by a simple route by combining self assembled nanocapsules of amphiphilically modified chitosan with glycerophosphate di-sodium salt and glycerol. The potential as a depot drug delivery system was demonstrated in vivo through the therapeutic effect of ethosuximide (ESM) loaded nanogels, suppressing spike wave discharges (SWDs) in Long Evan rat model. Simultaneously clearance of gels from the site of… CONTINUE READING
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