Design and characterization of a new miniaturized rotating disk equipment for in vitro dissolution rate studies.

@article{Persson2008DesignAC,
  title={Design and characterization of a new miniaturized rotating disk equipment for in vitro dissolution rate studies.},
  author={Anita Maria Persson and Kajsa Baumann and L Sundel{\"o}f and Walter Lindberg and Anders Sokolowski and Curt Pettersson},
  journal={Journal of pharmaceutical sciences},
  year={2008},
  volume={97 8},
  pages={3344-55}
}
A miniaturized apparatus for the determination of the apparent in vitro dissolution rate has been designed, constructed and characterized. The miniaturized apparatus was based on a low volume dissolution cell and a disk in a rotating magnetic bar. The disk tablet is pressed directly into the bar with a press designed and constructed for this purpose. It requires approximately 5 mg of substance. The disk was positioned eccentrically on the bar with an external flow of medium to increase the rate… CONTINUE READING