Design and characterization of a fluorescent ghrelin analog for imaging the growth hormone secretagogue receptor 1a

@article{Mcgirr2011DesignAC,
  title={Design and characterization of a fluorescent ghrelin analog for imaging the growth hormone secretagogue receptor 1a},
  author={Rebecca Mcgirr and Mark S. McFarland and J. McTavish and L. Luyt and S. Dhanvantari},
  journal={Regulatory Peptides},
  year={2011},
  volume={172},
  pages={69-76}
}
  • Rebecca Mcgirr, Mark S. McFarland, +2 authors S. Dhanvantari
  • Published 2011
  • Biology, Medicine
  • Regulatory Peptides
    • Ghrelin is a 28-amino acid peptide hormone produced in the stomach. It binds to the growth hormone secretagogue receptor 1a (GHS-R1a), a class A G-protein-coupled receptor. In the present study, we describe the design, synthesis and characterization of a truncated, 18-amino acid analog of ghrelin conjugated to a fluorescent molecule, fluorocein isothiocyanate (FITC), through the addition of a lysine at its C terminus ([Dpr(octanoyl)(3), Lys(fluorescein)(19)]ghrelin(1-19)). Receptor binding… CONTINUE READING
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