Design and characterization of a broad -spectrum bactericidal acyl-lysyl oligomer.

@article{Livne2009DesignAC,
  title={Design and characterization of a broad -spectrum bactericidal acyl-lysyl oligomer.},
  author={L. Livne and Tchelet Kovachi and H. Sarig and R. Epand and Fadia Zaknoon and A. Mor},
  journal={Chemistry \& biology},
  year={2009},
  volume={16 12},
  pages={
          1250-8
        }
}
Previously characterized chemical mimics of host defense peptides belonging to the oligo-acyl-lysyl (OAK) family have so far failed to demonstrate broad-spectrum antibacterial potency combined with selectivity toward host cells. Here, we investigated OAK sequences and characterized a promising representative, designated C(12)K-3beta(10), with broad-spectrum activity (MIC(90) = 6.2 microM) and low hemotoxicity (LC(50) > 100 microM). Whereas C(12)K-3beta(10) exerted an essentially bactericidal… Expand

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