Design and application of microfluidic systems for in vitro pharmacokinetic evaluation of drug candidates.

@article{Maguire2009DesignAA,
  title={Design and application of microfluidic systems for in vitro pharmacokinetic evaluation of drug candidates.},
  author={Timothy J Maguire and Eric M Novik and Piyun B Chao and Jeffrey A Barminko and Yaakov Nahmias and Martin L. Yarmush and K C Cheng},
  journal={Current drug metabolism},
  year={2009},
  volume={10 10},
  pages={1192-9}
}
One of the fundamental challenges facing the development of new chemical entities within the pharmaceutical industry is the extrapolation of key in vivo parameters from in vitro cell culture assays and animal studies. Development of microscale devices and screening assays incorporating primary human cells can potentially provide better, faster and more efficient prediction of in vivo toxicity and clinical drug performance. With this goal in mind, large strides have been made in the area of… CONTINUE READING

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