Design and application of locally delivered agonists of the adenosine A(2A) receptor.

@article{Mantell2010DesignAA,
  title={Design and application of locally delivered agonists of the adenosine A(2A) receptor.},
  author={Simon John Mantell and Rhys Alwyn Jones and Mike A Trevethick},
  journal={Expert review of clinical pharmacology},
  year={2010},
  volume={3 1},
  pages={
          55-72
        }
}
The broad spectrum anti-inflammatory actions of adenosine A(2A) receptor agonists are well described. The wide distribution of this receptor, however, suggests that the therapeutic potential of these agents is likely to reside in topical treatments to avoid systemic side effects associated with oral administration. Adenosine A(2A) receptor agonists have been assessed as topical agents: GW328267X (GSK; allergic rhinitis and asthma), UK-432097 (Pfizer; chronic obstructive pulmonary disease [COPD… CONTINUE READING
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