Design and Synthesis of Novel Hybrid Molecules against Malaria

  title={Design and Synthesis of Novel Hybrid Molecules against Malaria},
  author={Melanie Loedige and Luisa Hiersch},
  booktitle={International journal of medicinal chemistry},
The effective treatment of malaria can be very complex: Plasmodium parasites develop in multiple stages within a complex life cycle between mosquitoes as vectors and vertebrates as hosts. For the full and effective elimination of parasites, an effective drug should be active against the earliest stages of the Plasmodium infection: liver stages (reduce the progress of the infection), blood stages (cure the clinical symptoms), and gametocytes (inhibit the transmission cycle). Towards this goal… CONTINUE READING
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