Design and Synthesis of 3-( 3-Chloro-4-substituted phenyl )-4-( pyridin-4-yl )-1 H-pyrazole-1-carboxamide Derivatives and Their Antiproliferative Activity Against Melanoma Cell Line

Abstract

Design and synthesis of new 3,4-diarylpyrazole-1-carboxamide derivatives are described. Their antiproliferative activity against A375 human melanoma cell line was tested and the effect of substituents on the diarylpyrazole scaffold was investigated. The pharmacological results indicated that most of the synthesized compounds showed moderate activity against… (More)

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