Design and Statistical Analysis of Pooled Next Generation Sequencing for Rare Variants

Abstract

Next generation sequencing NGS is a revolutionary technology for biomedical research. One highly cost-efficient application of NGS is to detect disease association based on pooled DNA samples. However, several key issues need to be addressed for pooled NGS. One of them is the high sequencing error rate and its high variability across genomic positions and… (More)

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Cite this paper

@inproceedings{Wang2014DesignAS, title={Design and Statistical Analysis of Pooled Next Generation Sequencing for Rare Variants}, author={Tao Wang and Chang-Yun Lin and Yuanhao Zhang and Ruofeng Wen and Kenny Ye and Wei T. Pan}, year={2014} }