Design and Evaluation of the Highly Concentrated Human IgG Formulation Using Cyclodextrin Polypseudorotaxane Hydrogels

@article{Higashi2015DesignAE,
  title={Design and Evaluation of the Highly Concentrated Human IgG Formulation Using Cyclodextrin Polypseudorotaxane Hydrogels},
  author={Taishi Higashi and Anna Tajima and Naoko Ohshita and Tatsunori Hirotsu and Irhan Ibrahim Abu Hashim and Keiichi Motoyama and Sawako Koyama and Ruriko Iibuchi and Shiuhei Mieda and Kenji Handa and Tomoaki Kimoto and Hidetoshi Arima},
  journal={AAPS PharmSciTech},
  year={2015},
  volume={16},
  pages={1290-1298}
}
To achieve the potent therapeutic effects of human immunoglobulin G (IgG), highly concentrated formulations are required. However, the stabilization for highly concentrated human IgG is laborious work. In the present study, to investigate the potentials of polypseudorotaxane (PPRX) hydrogels consisting of polyethylene glycol (PEG) and α- or γ-cyclodextrin (α- or γ-CyD) as pharmaceutical materials for highly concentrated human IgG, we designed the PPRX hydrogels including human IgG and evaluated… CONTINUE READING