Design and Analysis of Single-Cell Sequencing Experiments

@article{Grn2015DesignAA,
  title={Design and Analysis of Single-Cell Sequencing Experiments},
  author={Dominic Gr{\"u}n and Alexander van Oudenaarden},
  journal={Cell},
  year={2015},
  volume={163},
  pages={799-810}
}
Recent advances in single-cell sequencing hold great potential for exploring biological systems with unprecedented resolution. Sequencing the genome of individual cells can reveal somatic mutations and allows the investigation of clonal dynamics. Single-cell transcriptome sequencing can elucidate the cell type composition of a sample. However, single-cell sequencing comes with major technical challenges and yields complex data output. In this Primer, we provide an overview of available methods… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 106 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 78 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 78 references

Similar Papers

Loading similar papers…