# Design Space Toolbox V2: Automated Software Enabling a Novel Phenotype-Centric Modeling Strategy for Natural and Synthetic Biological Systems

@inproceedings{Lomnitz2016DesignST, title={Design Space Toolbox V2: Automated Software Enabling a Novel Phenotype-Centric Modeling Strategy for Natural and Synthetic Biological Systems}, author={Jason G. Lomnitz and Michael A. Savageau}, booktitle={Front. Genet.}, year={2016} }

- Published 2016 in Front. Genet.
DOI:10.3389/fgene.2016.00118

Mathematical models of biochemical systems provide a means to elucidate the link between the genotype, environment, and phenotype. A subclass of mathematical models, known as mechanistic models, quantitatively describe the complex non-linear mechanisms that capture the intricate interactions between biochemical components. However, the study of mechanistic models is challenging because most are analytically intractable and involve large numbers of system parameters. Conventional methods to… CONTINUE READING